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Association details:
| Biomarker: | ABCC2 3972C>T |
|---|---|
| Cancer: | Chronic Myeloid Leukemia |
| Drug: | Tasigna (nilotinib) (Bcr-abl tyrosine kinase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
POLYMORPHISMS IN MULTIDRUG RESISTANCE TRANSPORTER GENES AFFECT THE DURATION OF MOLECULAR RESPONSE TO NILOTINIB IN CHRONIC MYELOID LEUKEMIA PATIENTS
Published date:
05/17/2018
Excerpt:
Difference in genotype and allele’s distributions among the patients and the associations of the various genotype with response, resistance or loss of response to Nilotinib were determined….Analysis of the difference in genotype distribution and alleles frequencies in responders and non-responders to Nilotinib showed that ABCC2 3972C>T SNPs (rs3740066) significantly impact on the loss of MR3...
